This very large protein has been shown to be important with a multitude of roles including as a structural and signaling protein on cell membranes.24 It was previously reported that the downregulation of AHNAK was accompanied with high tumor potential.25 Proteins including FLNB (filamin-B), and TLN1 (talin-1) were also found to be inward hubs. This evidence concerns the gene FLNB and neoplasm.