Treatment with this combination of dietary antioxidants causes a decrease in the expression of phosphorylated mitogen-activated protein kinase (MAPK) family proteins, extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38, as well as an increase in total p53 and p-p53, which shows promise in suppressing the growth of mouse skin tumors [202]. Here, TP53 is linked to skin neoplasm.