EGFR and cancer: The accumulating evidence revealed that certain cancer-derived mutant forms of p53 transactivate various target genes, including multiple drug resistance gene 1 (MDR1), c-myc, proliferating cell nuclear antigen (PCNA), interleukin-6 (IL-6), insulin-like growth factor 1 (IGF-1), fibroblast growth factor (FGF), epidermal growth factor receptor (EGFR), asparagine synthetase (ASNS), and telomerase reverse transcriptase (TERT) [76, 88, 89].