In the present study, elevated autophagy and suppressed TLR4-modulated NF-κB pathway by AC extract treatment contribute to decreasing caspase-1, IL-1β, TNF-α, and NLRP3 expressions, which might be beneficial to attenuation of caspase-dependent pathways of apoptosis and explanation of relationship among inflammation, autophagy, and apoptosis, embodying multiple therapeutic advantages of AC extract on ischemic stroke. The gene discussed is TNF; the disease is ischemic stroke.