Due to CBF interruption after stroke, several DAMPs (e.g., high mobility group box 1, heat-shock proteins, and nucleic acids) are derived from injured and necrotic cells release, and simultaneously, BBB disruption is implicated in leukocyte infiltration into the brain parenchyma, both of which contribute to the initiation of postischemic inflammation [6, 25]. The gene discussed is HMGB1; the disease is Stroke.