In the present study, elevated autophagy and suppressed TLR4-modulated NF-κB pathway by AC extract treatment contribute to decreasing caspase-1, IL-1β, TNF-α, and NLRP3 expressions, which might be beneficial to attenuation of caspase-dependent pathways of apoptosis and explanation of relationship among inflammation, autophagy, and apoptosis, embodying multiple therapeutic advantages of AC extract on ischemic stroke. This evidence concerns the gene TLR4 and ischemic stroke.