Evidence illustrates that mitochondria-dependent intrinsic apoptotic pathway activating caspase-3 not only arouses apoptotic cell death but also inhibits autophagy in ischemic stroke resulting from antiapoptotic protein Bcl-2 binding to Beclin-1 [13], so suppressed apoptosis and increased autophagy contributed to the recovery of hippocampus injury in cerebral ischemia/reperfusion rats [14]. Here, CASP3 is linked to brain ischemia.