NLRP3 and Cerebral ischemia: Presently, NF-κB signaling has been demonstrated to involve in the activations of NLRP1 and NLRP3 inflammasomes, and inhibition of the pathway not only decreases interleukin- (IL-) 1β, IL-18, tumor necrosis factor- (TNF-) α, and IL-6 but also attenuates apoptotic cells in cerebral tissue after cerebral ischemia [10, 11].