Tumor volume results monitored and measured by MRI showed that intranasal administration of TGF-β1 significantly increased the volume of tumors while NOX4 suppressed with GKT137831 undertreated with TGF-β1 administration reduced tumor volume compared with TGF-β1 administration alone (Figures 7(a)–7(c)). Here, NOX4 is linked to neoplasm.