Kinugawa et al. [102] explored the role of OS in left ventricular remodeling and failure after myocardial infarction in mice and whether the -OH scavenger dimethylthiourea can alleviate these changes, and compared with untreated mice, mice who received dimethylthiourea demonstrated inhibition of MMP-2 activation, significantly improved left ventricular contractility, and reduced left ventricular hypertrophy. Here, MMP2 is linked to myocardial infarction.