In another study, too, it was shown that Foxp3+Helios+ Tregs, unlike Foxp3+Helios− cells, were found in high numbers in SLE patients and were positively correlated with disease activity, but this was not observed in systemic sclerosis (SSc) or RA [51, 52]. The gene discussed is FOXP3; the disease is systemic lupus erythematosus.