In addition, it was also shown that the Foxp3+Helios− subset may contain cytokine-producing conventional T cells, which produce IL-2 or IFN-γ, but the Foxp3+Helios+ population comprised only non-cytokine-producing cells in both SLE patients and healthy controls [51]. The gene discussed is FOXP3; the disease is systemic lupus erythematosus.