Adjusted for age, gender, education, and subtype, we demonstrated that the multivariate risk of cognitive impairment was higher in excessive drinkers than in nondrinkers with the ALDH2 wild-type genotype, while the risk of cognitive impairment was higher in light to excessive drinkers than nondrinkers with the ALDH2 mutant or heterozygous genotype. This evidence concerns the gene ALDH2 and Cognitive impairment.