Although several peripheral blood protein tumor markers are capable of enhancing early diagnosis rate, such as carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA), cytokeratin 19 fragment antigen (CYFRA21-1), and mucin 16 (CA125), it is unable to be promoted well in clinical practice owing to low sensitivity and specificity [5]. This evidence concerns the gene MUC16 and neoplasm.