As JAK-1 inhibitors are a new promising drug family for treating AD and due to the lack of evidence regarding the new drug called abrocitinib, although there are very few systematic reviews that talk about abrocitinib and atopic dermatitis, this systematic review examined several outcomes and different doses 100 and 200 mg of treatment, resulting in a good evidence that may serve as a good reference to atopic dermatitis guidelines. The gene discussed is JAK1; the disease is atopic eczema.