Importantly, the results showed that p38 MAPK pathway inhibition after SB203580 pretreatment significantly reduced the migration and invasion abilities of these NPC cells even directly cultured in the medium containing 1 μg/ml S100A8/A9 (P < 0.05 and P < 0.01, respectively (Figures 3(a)–3(d))). This evidence concerns the gene IGKV1D-22 and nasopharyngeal carcinoma.