To explore the effects of exogenous S100A8/A9 on NPC cell proliferation, we treated the NPC cells with S100A8/A9 at different concentrations to mimic S100A8/A9 infiltrated NPC microenvironment and detected cell proliferation by CCK8 assay. The gene discussed is IGKV1D-22; the disease is nasopharyngeal carcinoma.