In addition, the positive staining area percentages of S100A8 and S100A9 in advanced stage NPC (III stage or IV stage) were significantly higher than those in early stage NPC (II stage) (P < 0.01, respectively) (Table S2), while the III stage and IV stage were not statistically different (Figures 1(b) and 1(d) and Table S2). The gene discussed is S100A8; the disease is nasopharyngeal carcinoma.