Intriguingly, all the three databases (GEPIA, UALCAN, and DriverDBv3) demonstrated that increased YAP1 expression was correlated with poor prognosis in adrenocortical carcinoma (ACC), brain lower-grade glioma (LGG), and pancreatic adenocarcinoma (PAAD), suggesting YAP1 might be a prognostic biomarker in ACC, LGG, and PAAD. Here, YAP1 is linked to central nervous system cancer.