As increased chaperone activities are a universal feature of cancer [28], Hsp70-Tomm34-Hsp90 has been confirmed to be upregulated in a variety of cancers, including liver cancer [16], lung cancer [29], gastric cancer [30] and breast cancer [31], etc. Several studies have reported the immunoreactivity of Hsp70 and Hsp90 in OSCC, which were corelated with poor prognosis [32–35]. Here, TOMM34 is linked to cancer.