During their first treatment a total of 6 patients received rituximab; besides the two HL patients treated with ABVD there was one more patient who did not receive rituximab, she was initially diagnosed with GZL and was treated with brentuximab-vedotin in addition to the CHOP regime due to CD20 negativity and strong CD30 positivity. Here, TNFRSF8 is linked to Hodgkins lymphoma.