TRAF3 and cancer: Both of the TRAF3 mutations (p.Asn285ThrfsX38 and p.Asn285LysfsX13) identified in the present study would result in production of the ring domain and the zinc finger domain without the TRAF-N and TRAF-C domains [3], which might lose the activities or be degraded by nonsense-mediated mRNA decay that is frequently present in MSI-H cancers [14].