Investigations on the association of NOTCH1 rs3124591, NOTCH3 rs1043994, and NOTCH4 rs3830041 with the risk of human cancers are rare, however, several studies have shown a link between NOTCH2 related rs11249433 and increased risk of breast cancer especially in women of European ancestry [18–21]. The gene discussed is NOTCH1; the disease is breast cancer.