A recent study by Yu et al demonstrated that Chinese patients carrying the TT genotype of NOTCH4-rs3830041 had poorer overall survival in contrast to those carrying TC/CC genotype and concluded that rs3830041 variant is an independent predictive marker for prognosis in hepatitis B virus-related hepatocellular carcinoma patients [23]. The gene discussed is NOTCH4; the disease is hepatocellular carcinoma.