However, Campa et al did not observe similar association of this SNP with risk of breast cancer by ER status [20] Another study indicated that the NOTCH2 rs11249433 was associated with the risk of breast cancer for patients who are BRCA2 mutation carrier, but was not associated with the risk of breast cancer for BRCA1 mutation carriers [36]. Here, NOTCH2 is linked to breast carcinoma.