The distribution of genotypes for all the four SNPs in control group as well as NOTCH3 rs1043994 and NOTCH4 rs3830041 in breast cancers followed Hardy-Weinberg equilibrium while SNPs rs3124591 in NOTCH1 (p = 0.046275) and NOTCH2 related rs11249433 (p = 0.000095) in breast cancers deviated from Hardy-Weinberg equilibrium (Table 1). The gene discussed is NOTCH2; the disease is breast cancer.