TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Although immunohistochemistry (IHC) can detect the overexpression of TFE3 protein that is involved in TFE3 gene, serving as the basic method for diagnosis of Xp11.2 tRCC, high false-positive rates and low predictive values were reported [7].