The long noncoding RNA MALAT1 is overexpressed in numerous cancers and plays a key role in cell proliferation and metastasis via the modulation of the PI3K/AKT [22], NF-kB [23], WNT/β-catenin [24], MAKP/ERK [25] and other molecular signaling pathways. The gene discussed is NFKB1; the disease is cancer.