SOX2 and cervical squamous intraepithelial neoplasia: Within the top 250 differentially expressed genes, the canonical Wnt signaling genes Wnt3a, CTNNB1 (β-catenin), and CREBBP (CBP) were significantly upregulated in the samples of precancerous and cancer of the cervix compared with those of the normal cervix, thereby contributing to the distinct upregulation of their downstream transcription factors KLF4, MYC, and SOX2, except KLF4 slightly downregulated in CIN (Figure 1B).