Consistent with the activation of CBP/β-catenin, markers of TICs CK17, CK14, TP63 and P16 were upregulated, while markers of squamous cell differentiation LORICRIN, INVOLUCRIN and CK4 were downregulated significantly in the CIN and SCC samples compared with normal cervix samples. The gene discussed is KRT4; the disease is cervical squamous intraepithelial neoplasia.