We analyzed the prognostic value of LINC00528 for all 31 diseases included by GEPIA and found that the high expression of LINC00528 was associated with better overall survival in breast invasive carcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, head and neck squamous cell carcinoma, lung adenocarcinoma and skin cutaneous melanoma, while the high expression of LINC00528 was associated with worse overall survival in acute myeloid leukemia, stomach adenocarcinoma and uveal melanoma (logrank p < 0.05). Here, LINC00528 is linked to cutaneous melanoma.