It is worth noting that the expression level of LINC00528, to a certain extent, can distinguish between patients with early HER2-positive breast cancer and patients with advanced HER2-positive breast cancer: the expression level of LINC00528 in early HER2-positive breast cancer patients (T1/2) was higher than that in advanced HER2-positive breast cancer patients (T3/4) (t = 1.930803441, p = 0.060616568). The gene discussed is LINC00528; the disease is breast cancer.