In order to clarify the expression pattern of HMGB1 in fibroblastic sarcomas, the staining of HMGB1 were detected by IHC assay in 95 TMA cores of fibroblastic sarcomas, which included 54 cases of DFSP, 12 cases of MFS and 29 cases of ATFS. The gene discussed is HMGB1; the disease is sarcoma.