Moreover, correlation analysis revealed that HMGB1 cytoplasm-staining score and HMGB1 total score were related to tumor grade (p = 0.0049, r = 0.2863; p = 0.0005, r = 0.3508; respectively) (Figure 1C), whereas HMGB1 nucleus-staining score was not related (data not shown). Here, HMGB1 is linked to neoplasm.