As The Human Protein Atlas database (https://www.proteinatlas.org/) exhibits that NLRP9 expression is evident in normal stomach and colon cells and is strongest in colorectal cancers followed by gastric, pancreatic, testicular and liver cancers, but other cancer tissues are in general weakly stained or negative, suggesting its role in gastrointestinal tract. This evidence concerns the gene NLRP9 and liver cancer.