UCHL1 and colorectal cancer: For example, UCHL1 can stabilize and upregulate β-catenin/TCP-dependent transcription in colorectal cancer [18], can promote metastasis as a deubiquitinating enzyme for HIF-1a in lung cancer [19], can bypass the need for mTORC1-dependent protein synthesis to initiate MYC translation in lymphomas [20], and can enhance CDK activities in the pathogenesis of neurodegenerative diseases [21].