The oncoproteins Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are downstream components of this pathway, and deregulation of the Hippo pathway with activation of YAP and TAZ has been implicated in carcinogenesis, including HCC development [7, 8]. The gene discussed is WWTR1; the disease is hepatocellular carcinoma.