YAP expression has previously been demonstrated in a substantial proportion of K19+/EpCAM + HCCs and combined hepatocellular-cholangiocarcinomas [11, 15], and it was therefore suggested that the Hippo signaling pathway may be involved in the acquisition of stemness features of HCCs and combined hepatocellular-cholangiocarcinomas [15]. Here, EPCAM is linked to cholangiocarcinoma.