Also, many signaling pathways, such as ANGIOGENESIS, P53 PATHWAY, EPITHELIAL MESENCHYMAL TRANSITION (EMT) and MYC TARGETS V1, were enriched in the groups with upregulated expression level of these hub genes, suggesting their contribution to the occurrence, progression and tumor microenvironment of HCC. The gene discussed is TP53; the disease is hepatocellular carcinoma.