High EZH2 expression was demonstrated in 44.4% of the cases of malignant mesothelioma in the current study; which is less than what was recorded in Shinozaki-Ushiku et al. [4], whose frequency of high EZH2 expression was 57%, but was similar to the percentage reported in Yoshimura et al. [15], whose malignant mesothelioma cases showed high EZH2 expression in 44.7%. This evidence concerns the gene EZH2 and malignant mesothelioma.