IL-10 is mainly produced by Th2 cells. As an immunosuppressive factor that is generally thought to support tumor growth and progression. Similarly to CD8+ tregs and CD56+ NK cells, high expression of IL-10 in tumor tissue was also related with increased invasiveness of NFPAs. IL-10 may present a useful biomarker for diagnosis of invasive NFPAs. This evidence concerns the gene IL10 and neoplasm.