CD274 and neoplasm: Unfortunately, the correlation between PD-L1 expression in tumor cells and treatment response to immunotherapy is not uniformly accurate; in some instances, almost 10% of patients with negative PD-L1 tumors have meaningful responses to ICIs [10, 11]; this inaccuracy of PD-L1 expression as a reliable biomarker to predict ICIs response could be explained by the wide variety of PD-L1 assays methods, different PD-L1 thresholds used to define positiveness, the quality of analyzed tissue, and different type of cells assessed in each study.