NOTCH1 and medical procedure: To determine whether Notch1 deficiency due to genomic aberrations can also be observed in human mutated KRAS driven ADCs, we used TCGA database and investigated the publicly available lung ADC dataset containing 230 cases [22] for genomic aberrations in KRAS and NOTCH1. We found ten genomic alterations in NOTCH1 (4.3%) (Table 1), of which five were putative loss-of-function aberrations (2.15%).