NOTCH1 and neoplasm: The determined tumor area upon Notch1 knock-out was slightly decreased from 24.68 to 17.90% (p = 0.1672) as well as tumor cell proliferation, indicated by the KI67 index, from 21.00 to 17.86% (p = 0.3034) in a dose-dependent manner, though not significantly, comparing R+ N1w/w and R+ N1f/f mice (Figures 2A–C).