Intriguingly, tumor cell accumulation inside the bronchiolar lumen with proliferating cells which protrude from the bronchiolar lining, was significantly increased both upon the loss of one Notch1 allele [from 9.82 to 28.40% (p = 0.0390)] and the loss of two Notch1 alleles [from 9.82 to 40.34% (p = 0.0020)] (Figure 2D). Here, NOTCH1 is linked to neoplasm.