When Bcl-2 was in a low-expression state, there was no survival difference in ESCC patients regardless of their expression levels of Beclin-1 (high expression of Beclin-1 and low expression of Bcl-2 group vs. low expression of both Beclin-1 and Bcl-2 group; 46.82 ± 4.75 vs. 44.80 ± 3.86; p > 0.05; Figure 2D). The gene discussed is BCL2; the disease is esophageal squamous cell carcinoma.