As is shown in Figures 9A–J, Over-expression of CDK1 (p < 0.0001), CCNB1 (p < 0.0001), AURKA (p = 0.0016), CCNA2 (p = 0.00055), KIF11 (p < 0.0001), BUB1B (p = 0.00087), TOP2A (p = 0.00031), TPX2 (p < 0.0001), HMMR (p < 0.0001) and CDC45 (p < 0.0001) was associated with poor overall survival (OS) among TCGA HCC patients in UALCAN. This evidence concerns the gene TOP2A and hepatocellular carcinoma.