Similar anti-tumor effects were observed in colorectal tumor cells after exposure to water extract of GR [19]; this treatment suppressed the cell viability and metastatic phenotype as well as activated Caspase-3 (Cas-3) and Poly (ADP-ribose) polymerase (PARP) in CT26 cells and BALB/c model tail vein injected with CT26 cells [19]. Here, EFS is linked to colorectal neoplasm.