In summary, the present study quantified the changes of LINC-PINT expression in LSCC tissues and in the LSCC cell line TU-177 and Hep-2 carcinoma cells and elucidated the inhibitory functions and action mechanism of LINC-PINT on LSCC development, suggesting a prognostic marker and a potent therapeutic direction for LSCC treatment. Here, LINC-PINT is linked to carcinoma.