Two estrogen-responsive element (ERE) half sites were reported in the promoter region of PELP1, and in the breast, endometrial as well as osteosarcoma model cancer cell lines, ERα or ERβ could be recruited to the promoter region of PELP1 and up-regulate the transcription of PELP1 [34]. The gene discussed is ESR2; the disease is osteosarcoma.