In addition, SP1 expression was linked with lymph node metastasis (OR = 0.42; 95%CI:0.28-0.64; p < 0.05) (Figure 2A), advanced TNM stage (OR = 0.34; 95%CI:0.20-0.57; p < 0.05) (Figure 2B) and infiltration depth (OR = 0.33; 95%CI:0.18-0.60; p < 0.05) (Figure 3A) which was independent of gender (OR = 1.09; 95%CI:0.88-1.34; p > 0.05) (Figure 1B). Here, SP1 is linked to metastatic malignant neoplasm in the lymph nodes.