NFAT2 and NFAT3 induce apoptosis in HCC [6] and glioma cells [22], respectively; NFAT4 deficiency results in the development of mammary gland adenocarcinoma [23]; NFAT5 inhibits invasion and promotes the apoptosis of HCC cells [8]. Here, NFATC4 is linked to hepatocellular carcinoma.