Consistently, NFAT5 protein expression was upregulated in the NSCLC cell lines A549 and H1975, and NFAT5 promoted the proliferation and migration of A549 and H1975 cell lines by regulating the expression of Aquaporin-5 that is involved in the proliferation, metastasis, and invasion of LC [14]. This evidence concerns the gene AQP5 and laryngotracheoesophageal cleft.