Consistently, NFAT5 protein expression was upregulated in the NSCLC cell lines A549 and H1975, and NFAT5 promoted the proliferation and migration of A549 and H1975 cell lines by regulating the expression of Aquaporin-5 that is involved in the proliferation, metastasis, and invasion of LC [14]. The gene discussed is AQP5; the disease is non-small cell lung carcinoma.