Since the first study regarding the correlation between NFAT1/5 and cancer cells was published [6], one or more members of the NFAT family have been reported to be dysregulated in numerous cancer types including hepatocellular carcinoma (HCC) [7, 8], breast cancer [9, 10], colorectal cancer [11, 12], and lung cancer (LC) [13–15]. The gene discussed is NFATC2; the disease is laryngotracheoesophageal cleft.