IDH2 and central nervous system neoplasm: Based on these studies, a previous report by the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy (cIMPACT-NOW) update 3 proposed that certain IDH-wild-type diffuse astrocytomas show a poor clinical course similar to IDH-wild-type glioblastomas, and that the characteristics of these tumours were a result of at least one of three genetic profiles: combined whole chromosome 7 gain and whole chromosome 10 loss (+ 7/− 10); and/or EGFR amplification; and/or TERT promoter (TERTp) mutation15.