The depletion in the levels of MDSCs, Tregs and the increase of OX40 along antineoplastic treatment, whether this is hormonotherapy alone, chemotherapy, hormonotherapy plus cyclin-dependent kinase inhibitors 4/6, or other combined strategies, could improve immune profile of the patients reverting their immunosuppressive status with respect to cancer cells. The gene discussed is TNFRSF4; the disease is cancer.