POLE and glioblastoma: Two of the patient’s separately appearing glioblastomas within different locations (corpus callosum and temporal lobe) were sequenced and hypermutated phenotype was shown with mutations in genes TP53, SETD2, ATRX, PTEN, POLE, BLM, ARID1A, APC, KDM6A, PTPN11, and BRCA2, which are predominantly involved in DNA repair.