MSH6 and central nervous system cancer: The third patient with hemispheric high-grade glioma had wildtype histone H3 and demonstrated a hyper-mutated genotype with mutations in ATRX, TP53, CDKN2A, SETD2, MSH6, and PDGFRA. These genes are involved in the DNA repair pathway, regulation of cell cycle progression, and signaling via ERK pathway (Supplementary Tables 1, 2).