While the group’s average seroreactivity to the extracellular CD36-binding and CD36-associated PfEMP1 subgroups remained constant across the year overall after decreasing in the dry season and increasing in the malaria transmission season, the group experienced increased seroreactivity to the EPCR/ICAM-1-binding PfEMP1s across the entire year. Here, ICAM1 is linked to malaria.