The results show that 35 medicines included in the Prescrire 2019 “Drug to avoid” list are listed on the PBS including 16 medicines (46%) with substantial use: the five DPP-4 inhibitors for diabetes, four medicines indicated in the treatment of Alzheimer’s disease, four antidepressants, denosumab in osteoporosis, olmesartan and celecoxib. Here, DPP4 is linked to early-onset autosomal dominant Alzheimer disease.