The results show that 35 medicines included in the Prescrire 2019 “Drug to avoid” list are listed on the PBS including 16 medicines (46%) with substantial use: the five DPP-4 inhibitors for diabetes, four medicines indicated in the treatment of Alzheimer’s disease, four antidepressants, denosumab in osteoporosis, olmesartan and celecoxib. This evidence concerns the gene DPP4 and diabetes mellitus.