The genes targeted by the 7 T/N-downregulated miRNAs, which should result presumably upregulated in the tumor with respect to normal tissue, showed the highest enrichment for oncogenic pathways such as EMT pathway, AKT signaling, and mTOR signaling, but also for ATF2 signaling, TGF-beta signaling, VEGF A signaling and other less specific cancer sustaining pathways (Fig. 5, Panel a). This evidence concerns the gene AKT1 and neoplasm.