In particular from this work, coupled with the study of DNVs in neurodevelopmental disorders more broadly, there are now > 100 genes with genome-wide significance for excess of coding variation [50, 51, 59] including the gene EBF3. Recent ongoing efforts looking at common variation are providing insights into other aspects of the genetics of autism and explain ~ 50% of autism risk [60]. This evidence concerns the gene EBF3 and neurodevelopmental disorder.