HES1 and Hepatic fibrosis: It has been found in zebrafish that inhibition of Notch signaling can promote the differentiation of liver progenitor cells into hepatocytes, thus promoting liver regeneration [48].In this study, hUC-MSC transplantation significantly decreased Notch1 receptor and downstream target genes Hes1 and p21 of Notch pathway in ACLF rats, suggesting that the effect of hUC-MSCs in inhibiting liver fibrosis and promoting liver regeneration may be mediated by downregulating of Notch signaling.