In this study, in rats with liver cirrhosis, only LPS injected without D-GalN resulted in a moderate increase in ALT, AST, and TBil levels, accompanied by a decrease in ALB levels, without changes in coagulation function, blood ammonia content, or hepatocyte necrosis, suggesting the successful establishment of a non-ACLF (ACLI) rat model. Here, GPT is linked to cirrhosis of liver.