The white blood cell count and c-reactive protein level in ACLF patients are significantly higher than those in patients without ACLF, and the white blood cell count and c-reactive protein level are positively correlated with the number of organ failure and the severity of the disease in ACLF patients, suggesting that SI may account for the pathogenesis of ACLF in patients with decompensated liver cirrhosis [10]. Here, CRP is linked to cirrhosis of liver.