In the present study, we found that miRNA-126 were markedly downregulated in the myocardium of AngII-infused rats, PIK3R2 is a target of miRNA-126, and AA supplementation was able to prevent pathological cardiac hypertrophy and fibrosis by upregulation of miR-126 and inhibition of PI3K/AKT signaling pathway. The gene discussed is AGT; the disease is cardiac hypertrophy.