AKT1 and cardiac hypertrophy: In the present study, we found that miRNA-126 were markedly downregulated in the myocardium of AngII-infused rats, PIK3R2 is a target of miRNA-126, and AA supplementation was able to prevent pathological cardiac hypertrophy and fibrosis by upregulation of miR-126 and inhibition of PI3K/AKT signaling pathway.