HLA-DRB5 and cancer: However, the cancer-intrinsic expression of the HLA-II signature (of the top five highly expressed genes, i.e., DRB1, DQB1, DRA, DRB5, and DPA1, from CCOs), was significantly associated with patient survival (Fig. 5c). Assessment of the prognostic impact of the expression of the five individual HLA-II genes (for the top 5 HLA-II genes from CCOs) also showed similar results (Supplementary Fig. 7a).