POLE and small cell lung carcinoma: Gene centric analysis with Intogen demonstrated recurrent mutations in PIK3CA, PTEN, FBXW7 and POLE. Pathway analysis of the genes present in the pathCR group but not the non-responder group demonstrated 14 pathways (Table 1) being significantly over-represented in the dataset including hsa05210 (Colorectal Cancer, p = 1.88 × 10−16, q = 1.62 × 10−14), hsa05222 (Small cell lung cancer, p = 8.43 × 10−12, q = 3.63 × 10−10), and hsa04150 (mTOR pathway, p = 4.99 × 10−10, q = 1.43 × 10−8), all of which contain genes involved in the mTOR/AKT pathway.