Although diabetes alone showed effects on chromatin accessibility (with motif analysis implicating PU.1, RUNX1, and CCCTC-binding factor), the effects of IL-1β, in the context of cells that were primed by diabetes, was even more pronounced (and implicated ERG, ZNF263 [zinc finger protein 263], and RUNX1). Here, RUNX1 is linked to diabetes mellitus.