It is interesting that some of these RUNX1 target genes display increased expression in plaque macrophages from patients with diabetes, namely CRNKL1 and PLA2G5, whereas others, like ZNF32 (zinc finger protein 32) and NUP214 (nucleoporin 214), displayed lower expression in diabetic versus nondiabetic plaque macrophages. Here, RUNX1 is linked to diabetes mellitus.