These target genes include diabetes-induced DE of atherosclerosis relevant genes such as Traf3ip3 (log fold change, 0.56; FDR, 0.02),48Crnkl1 (log fold change, 0.63; FDR, 0.04),49 and Pla2g5 (log fold change, 0.16; FDR, 0.1).50 This evidence concerns the gene PLA2G5 and atherosclerosis.