After additional adjustment for serum creatinine level, ALT, hyperthyroidism, hypertension, hyperlipidemia, high calcium diet, long-term systemic steroid use, oophorectomy, the HR for osteoporosis in the diabetes group was 1.37 (95% CI: 1.11–1.69; p = 0.004). The gene discussed is GPT; the disease is hyperthyroidism.