To test whether increased p21 was associated with increased senescence in E6* expressing cervical cancer, SiHa (parent), SiHa E6*, and SiHa E6 overexpressing cells were plated and grown for 8 days and then stained for senescence-associated β-galactosidease (SA-β-gal) expression, and senescent cells were quantified. This evidence concerns the gene CDKN1A and cervical cancer.