Lynch syndrome–associated genes such as PMS2 (314/10,085, 3.1%), MSH6 (284/10,085, 2.8%), MLH1 (283/10,085, 2.8%), MSH2 (270/10,085, 2.7%), and EPCAM (42/10,085, 0.04%) were queried less frequently. The gene discussed is MSH6; the disease is Lynch syndrome.